Studies on dissolution behaviors of extended-release articles.
نویسندگان
چکیده
منابع مشابه
In Vitro Dissolution Studies of Immediate - Release and Extended - Release Formulations Using Flow - Through Cell Apparatus 4
The aims of this study were to evaluate the dissolution performance of solid dosage forms using the open and closed modes of the FTC Apparatus 4 under different flow rates and provide examples to demonstrate the advantages of the FTC method, in particular the possibility of changing the pH during experiments, in studying the release mechanisms of extended-release products. Immediate-release (IR...
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Drug dissolution studies are commonly conducted using compendial methods employing USP Paddle and Basket apparatuses. In many cases, dissolution studies can be of limited benefit especially for product-dependent dissolution procedures like in extended release (ER) formulations. The high variability in dissolution testing, that is not productrelated, emphasizes the need for developing new method...
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INTRODUCTION Nifedipine is a calcium-channel blocking agent that is widely used in the treatment of angina pectoris and systemic hypertension (1). The pharmacokinetics and pharmacodynamics of nifedipine have been investigated in numerous studies (2–4). Clinical experiences gained with oral nifedipine formulations with immediate-release (IR) characteristics clearly show that a steep rise in the ...
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ژورنال
عنوان ژورنال: Japanese Journal of Hospital Pharmacy
سال: 1987
ISSN: 2185-9477,0389-9098
DOI: 10.5649/jjphcs1975.13.345